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Difficulty in getting pregnant refers infertility i.e., not having conceived after 12 months of having regular unprotected sex. Common causes of difficulty in conceiving include problems with ovulation, tubal disease, endometriosis, increasing age, abnormality of uterus, and exposure to the hazardous chemicals, mental stress are also the reason for infertility in humans. These factors causes miscarriage, infertility in both men and women which affects the chances of conceiving, affects female ovulation.