2nd International Conference on
Renaissance London Heathrow Hotel, UK
Cancer Genetics explores how changes in DNA lead to the development and progression of cancer. These genetic alterations can be inherited (germline mutations) or acquired (somatic mutations) during a person’s life. Cancer develops when normal genes that regulate cell growth, division, and apoptosis are damaged, leading to uncontrolled cell proliferation. Critical genes involved include oncogenes, tumor suppressor genes, and DNA repair genes. Oncogenes, such as RAS and MYC, drive excessive cell growth when abnormally activated, while tumor suppressor genes like TP53 and BRCA1 lose their protective function when mutated. Defects in DNA repair genes, including MLH1 and MSH2, result in genomic instability and accumulation of further mutations. Advances in genetic testing and molecular profiling have revolutionized cancer diagnosis and treatment, enabling targeted therapies tailored to an individual’s genetic makeup. Understanding cancer genetics is vital for early detection, personalized medicine, and the development of more effective cancer prevention strategies.
