The skin in the neonatal period is engrossing. During this period, the outer protective layer of our body adapts rapidly from a sterile aqueous environment to a dry environment rich with many new exposures. The variation occur in a way that is not readily visible in other organs. Most of the benign rashes appear in the neonatal period, which often mimic more worrisome rashes. Pediatric Dermatologists are especially trained in dermatology and pediatrics. Although the pediatrician easily identifies many of those discussed, for example, erythema toxicum neonatorum, it is the less straight-forward cases where physicians struggle. With this comes many questions from parents, thus it is imperative for pediatricians to know when to confidently reassure parents, when treatments are necessary, and when a referral to dermatology is needed for a variety of birthmarks and rashes. Even more important is to recognize when a true emergency may be at hand.