Neonatal gastroenterology developed as a sub-specialty of pediatrics and gastroenterology. This is mainly occur due to digestive problems in infants. It is concerned with treating the gastrointestinal tract, liver and pancreas from infancy until age eighteen. The principal diseases it is concerned with are vomiting, infant regurgitation, abdominal pain, infant rumination syndrome, ulcer-like dyspepsia, irritable bowel syndrome, functional diarrhoea etc. Whenever nerves or muscles in any segment of the stomach related tract don't work with their ordinary quality and coordination, an individual creates side effects identified with motility issues. Whenever nerves or muscles in any part of the stomach related tract don't work with their ordinary quality and coordination, an individual creates side effects identified with motility issues. Gastrointestinal disorders in neonates range from minor to life threatening, and short- to long-term or chronic. Gastrointestinal (GI) endoscopic procedure a fetal and neonatal endoscopy has become an essential modality for evaluation and treatment of GI diseases. Complex gastrointestinal medical procedure is one of the basic techniques to treat GI issue in neonates.