Almost all faculty and students of the Immunology Program study molecular and cellular regulatory mechanisms that underlie maintenance of all immune system activities. Numerous such studies are focused on problems of cell and organogenesis and homeostasis, cellular activation and inactivation signal transduction pathways, transcriptional regulation, application of gene therapy for immune response modulation, integration of the immune system with other organs and systems, and, among other contemporary research problems. These efforts are in partnership with those groups working on developing therapies for a range of diseases and nearly every lab with a disease focus has an extent of translation that embodies these basic concepts of biomedical science: