Vaccine safety and ethics are integral components in the popular adoption and successful implementation of vaccination programs. They constitute those aspects that deal with physical safety-to ensure the vaccines do not cause harm as well as those aspects concerning the ethical tenets involved in their development, their distribution, and their administration. Through vaccines, millions of lives have been saved, and indeed, it was a major battle against infectious diseases. However, safety measures and ethical implications of its use have to be placed in consideration carefully; this is especially in the arena of public health.